New research published in Cell Reports – well done Ruhe

Ruhe’s PhD research is published today in Cell Reports in a collaborative paper with Tony Ng’s lab at KCL – read about it here! We showed that by sorting cargo onto the intraluminal vesicles of multivesicular bodies, the ESCRT-III-associated protein ALIX controls the quality of released exosomes. One of the proteins incorporated into exosomes in an ALIX-dependent manner was the immunosuppressive molecule PD-L1. ALIX-depletion thus modulated the cell’s immunosuppressive properties by preventing PD-L1 secretion. Great job the Ng lab for bringing this together.