We are a discovery research lab exploring how cells remodel their membranes and organelles, We want to know how the machineries that perform this remodelling are regulated and how they contribute to cellular and organismal health.
Our Research
Every cell in your body is enclosed by a lipid membrane and contains a variety of intracellular membrane bound compartments called organelles that compartmentalise the biochemical functions necessary for life. We are interested in the membrane trafficking pathways that allow communication between these organelles, how the integrity of these organellar membranes is maintained and how these membranes and organelles are reorganised during processes such as cell division and cell migration
See also our website at The Francis Crick Institute and King’s College London
Meet the Team
Guy joined the lab after completing a PhD from the Cambridge Institute for Medical Research and an undergraduate degree from Oxford. He is using a mixture of light microscopy, electron microscopy and proteomics to understand how membrane trafficking complexes function.
George joined us after completing a PhD from the university of Sheffield. She works across my lab and the Adrian Isaacs lab at the UCL UK-DRI. George is developing assays to understand how membrane and organellar integrity is preserved.
Matteo joined the lab in 2023 after a PhD under the direction of Luca Fava in the Armenise-Harvard Laboratory of Cell Division, University of Trento. Matteo is an EMBO Postdoctoral Fellow and a Marie Skłodowska-Curie Actions Postdoctoral Fellow looking at nuclear envelope remodelling during mitosis.
Iona is a postdoc who completed a PhD in the Gruneberg lab at the Dunn School in Oxford. Iona will be looking at organelle remodelling during cell division.
Lucian is a BiPAS PhD student from King's College London, supervised by Prof Mark Wallace in King's Chemistry. He is using in-vitro approaches to look at ESCRT assembly.
Alicja is a CRUK City of London PhD student, co-supervised with Prof. Vicky Sanz-Moreno from the Bart's Cancer Institute at QMUL. Alicja will be looking at nuclear envelope remodelling in melanoma.
Matija joined us as a BBSRC LIDO Ph.D student and is working on plasma membrane repair
Yuexuan is a PhD student jointly supervised with Giulia Zanetti at UCL/Birkbeck and the Francis Crick Institute. After a Natural Science undergraduate degree from Cambridge, she worked with the Derivery lab at the MRC-LMB and will be working on high resolution ultrastructural analysis of the secretory pathway.
Vlad is a computational biologist on the King's Centre for Doctoral Training for Digital Twins in Healthcare programme. He is jointly supervised with Katie Bentley in King's Informatics and the Francis Crick Institute and with Giles Hickson from the Sainte-Justine Hospital Research Center, Université de Montréal. Vlad will be working on models of cell division.
Gaby is a MRC-DTP student who joined us after working Andy Cope's lab in King's Centre for Inflammation Biology and Cancer Immunology. She is supervised with Igor Vivanco from the Institute of Pharmaceutical Sciences and will be working on membrane trafficking and growth factor receptor signalling.
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